Priority 9 from the Cavernoma PSP

UNCERTAINTY: What features of brain cavernoma lead to the development of epilepsy, or influence the severity of existing epilepsy? (JLA PSP Priority 9)
Overall ranking 9
JLA question ID 0035/9
Explanatory note Not available for this PSP
Evidence

Up to date systematic review: Rosenow F*, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, et al. Cavernoma-related epilepsy: Review and recommendations for management—Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2013;54(12): 2025-35. DOI: 10.1111/epi.12402

Out of date systematic review: Moran NF. Fish DR. Kitchen N. Shorvon S. Kendall BE. Stevens JM. Supratentorial cavernous haemangiomas and epilepsy: a review of the literature and case series.  Neurosurg Psychiatr. 1999; 66(5):561-8. http://jnnp.bmj.com/content/66/5/561.long

Reference to an up to date relevant and reliable systematic review which does not refer to uncertainty but could be extended: Al-Shahi Salman R. The outlook for adults with epileptic seizure(s) associated with cerebral cavernous malformations or arteriovenous malformations. Epilepsia. 2012;53 (SUPPL. 4):34-42. doi: 10.1111/j.1528-1167.2012.03611.x.
Health Research Classification System category  Neurological
Extra information provided by this PSP
Original uncertainty examples Not available
Comparison Aetiology; Prognosis
Submitted by From an existing research recommendation
Outcomes to be measured Change of symptoms; health related quality of life
PSP information
PSP unique ID 0035
PSP name Cavernoma
Total number of uncertainties identified by this PSP. 54  
Date of priority setting workshop 23 September 2015