Priority 7 Sight Loss and Vision PSP Childhood Disorders

UNCERTAINTY: Can vision be corrected in later life for people with amblyopia? (JLA PSP Priority 7)
Overall ranking 7
JLA question ID 0014c/7
Explanatory note Reliable up-to-date systematic reviews revealed important continuing uncertainties about treatment effects at the time of the PSP
Evidence

Li T, Shotton K. Conventional occlusion versus pharmacologic penalization for amblyopia. Cochrane Database of Systematic Reviews 2009, Issue 4. Art. No.: CD006460. DOI: 10.1002/14651858.CD006460.pub2.

Antonio-Santos A, Vedula SS, Hatt SR, Powell C. Interventions for stimulus deprivation amblyopia. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD005136. DOI: 10.1002/14651858.CD005136.pub2.

Taylor K, Elliott S. Interventions for strabismic amblyopia. Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD006461. DOI: 10.1002/14651858.CD006461.pub3.

Taylor K, Powell C, Hatt SR, Stewart C. Interventions for unilateral and bilateral refractive amblyopia. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD005137. DOI: 10.1002/14651858.CD005137.pub3.
Health Research Classification System category Eye
Extra information provided by this PSP
Original uncertainty examples This is an indicative uncertainty and was submitted 9 times, and the following submissions were merged to form this uncertainty: Can we help adults who have amblyopia? Can we determine whether adults with amblyopia can benefit from treatment or whether treatment is not suitable for them? Can we cure amblopia in adults where it first occurred (but was not resolved) in children? Can vision be corrected in later life for people with amblyopia? Can we restore vision to an adult lazy eye where the condition has been present since early childhood? Why are lazy eyes not corrected when one is over the age of 10? Can we restore visual acuity in children with a lazy eye who are over 8 years old? Can vision be recovered in the better eye of a treated but regresssed amblyopic patient in later life?
Systematic reviews that need updating or extending None identified
Ongoing controlled trials

Amblyopia and neurovascular coupling in the retina of humans NCT00312390 Recovery from amblyopia with cholinesterase inhibitors NCT01584076
Submitted by Clinicians
Outcomes to be measured Management and or change of symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs
PSP information
PSP unique ID 0014c
PSP name Sight Loss and Vision - Childhood Onset Eye Disorders
Total number of uncertainties identified by this PSP. 69  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop April and May 2013