Priority 2 from the Rare Musculoskeletal Diseases in Adulthood PSP

UNCERTAINTY: What is the cause of pain in people with rare metabolic bone disorders? (JLA PSP Priority 2)
Overall ranking 2
JLA question ID 0076/2
Explanatory note Not available for this PSP
Evidence

Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions.Kelly MH, Brillante B, Collins MT. Osteoporos Int. 2008 Jan;19(1):57-63.
Health Research Classification System category Musculoskeletal
Extra information provided by this PSP
Original uncertainty examples Why am I constantly in pain? ~ How do hormones impact on PFD lesions? There is a definite connection between pain levels and menstrual cycle, what is this due to? ~ Is there research to suggest there is any link to decreased strength and ability / increased pain and problems around the time of an OI women's periods? ~ FD:What is the source of bone pain?
Submitted by Individual survey submissions categorised by Health or Social Care Professionals, Organisations representing people with rare musculoskeletal diseases, people with rare musculoskeletal diseases, relatives/carers/friends, Other.  For full details of the type of submitter for each individual question, please see the spreadsheet of data held on the JLA website.
PSP information
PSP unique ID 0076
PSP name Rare Musculoskeletal Diseases in Adulthood
Total number of uncertainties identified by this PSP. 39  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 18 June 2018