Priority 6 from the Psoriasis PSP

Abbott, 2015 Evidence that TNF-α inhibitor therapy reduces depression in people who have chronic diseases (including those with psoriasis) though the effects are small.    Limited data available.  Further studies investigating a more detailed timeline of changes in depression, inflammatory biomarkers and disease activity status in patients with psoriasis (and other chronic diseases) are required. 

Armstrong 2013a Some evidence that mild and severe psoriasis is associated with an increased risk of myocardial infarction and stroke.  Severe psoriasis is also associated with an increased risk of cardiovascular mortality.  Some limitations.  Future studies needed - these should include more complete covariate adjustment and characterisation of psoriasis severity. 

Armstrong 2013b Evidence that psoriasis and psoriatic arthritis are associated with greater prevalence of hypertension.  Patients with severe psoriasis have greater odds of hypertension than those with mild psoriasis.  Some limitations with study.  Further studies are needed – specifically to elucidate the basic mechanisms underlying the association between psoriasis and hypertension, to explore the relationship between psoriasis and hypertension severity, and to examine the effects of systemic treatments for psoriasis on hypertension control. 

Please see the data sheet for further list of evidence considered.