Priority 3 from the Multiple Sclerosis PSP
|UNCERTAINTY: Which treatments are effective for fatigue in people with multiple sclerosis? (JLA PSP Priority 3)|
|JLA question ID||0016/3|
|Explanatory note||Reliable up-to-date systematic reviews have revealed important continuing uncertainties about treatment effects|
Tejani AM, Wasdell M, Spiwak R, Rowell G, Nathwani S. Carnitine for fatigue in multiple sclerosis. Cochrane Database of Systematic Reviews 2012, Issue 5. Art. No.: CD007280. DOI: 10.1002/14651858.CD007280.pub3.
Payne C, Wiffen PJ, Martin S. Interventions for fatigue and weight loss in adults with advanced progressive illness. Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No.: CD008427. DOI: 10.1002/14651858.CD008427.pub2.
|Systematic reviews that need extending or updating||
No reviews found
|Systematic reviews in preparation||
Heine M, Rietberg MB, van Wegen EEH, Port IVD, Kwakkel G. Exercise therapy for fatigue in multiple sclerosis (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.: CD009956. DOI: 10.1002/14651858.CD009956.
|Ongoing controlled trials||
TREating FAtigue in Multiple Sclerosis: Energy conservation management TREFAMS-E ISRCTN82353628
TREating FAtigue in Multiple Sclerosis: Aerobic training TREFAMS-A ISRCTN69520623
TREating FAtigue in Multiple Sclerosis: Cognitive behavioural therapy TREFAMS-C ISRCTN58583714
|Health Research Classification System category||Neurological|
|Extra information provided by this PSP|
|Original uncertainty examples||No examples provided. This is an indicative uncertainty and several submissions were merged to form this one.|
|Submitted by||16 patients ~ 6 carers ~ 9 clinicians|
|Outcomes to be measured||Management and or change of multiple sclerosis symptoms; adverse effects or complications; acceptability to patients or carers; time to return to work or normal activity; time in hospital and or needing health or social care services; health related quality of life; and costs.|
|PSP unique ID||0016|
|PSP name||Multiple Sclerosis|
|Total number of uncertainties identified by this PSP.||82 (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)|
|Date of priority setting workshop||July 2013|