Priority 4 from the Miscarriage PSP

UNCERTAINTY: To what extent do pre-existing medical conditions cause miscarriage? (e.g. vitamin deficiencies, diabetes, previous infertility, endometriosis, polycystic ovarian syndrome, menstrual irregularities, cervical factors, uterine anomalies, polyps, immunological factors or previous pregnancy complications e.g. caesarean section or preterm birth) (JLA PSP Priority 4)
Overall ranking 4
JLA question ID 0053/4
Explanatory note Examples of original survey submissions: What health predispositions in women increase the risk of miscarriage?; To what extent does PCOS affect the risk of miscarriage? What factors reduce that risk?; Are there any associations between preterm birth and miscarriage?
Evidence

Balogun OO, da Silva Lopes K, Ota E, Takemoto Y, Rumbold A, Takegata M, Mori R. Vitamin supplementation for preventing miscarriage. Cochrane Database of Systematic Reviews 2016, Issue 5. Art. No.: CD004073. DOI: 10.1002/14651858.CD004073.pub4.

Kyrgiou M, Mitra A, Arbyn M, Paraskevaidi M, Athanasiou A, Martin-Hirsch PPL, Bennett P, Paraskevaidis E. Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia. Cochrane Database of Systematic Reviews 2015, Issue 9. Art. No.: CD008478. DOI: 10.1002/14651858.CD008478.pub2.
Health Research Classification System category Reproduction
Extra information provided by this PSP
Submitted by 7 professionals ~ 43 women ~ 1 family, friends or colleagues
PSP information
PSP unique ID 0053
PSP name Miscarriage
Total number of uncertainties identified by this PSP. 58  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 14 October 2016