Priority 10 from the Mesothelioma PSP

UNCERTAINTY: What, if any, are the benefits of pleurectomy (pleurectomy/decortication) compared to no surgery, and which mesothelioma patients might benefit? (JLA PSP Priority 10)
Overall ranking 10
JLA question ID 0025/10 
Explanatory note Not available for this PSP
Evidence Systematic review - Sestini S, Billè A, Okiror L, Gisabella M, Pastorino U. Systematic review on pleurectomy/decortication in the multimodality treatment of malignant pleural mesothelioma. Sestini S et al. Lung Cancer Management Vol. 3, No. 4, Pages 345-354 , DOI 10.2217/lmt.14.26.  Ongoing study - MARS 2: A Feasibility Study Comparing (Extended) Pleurectomy Decortication Versus no Pleurectomy Decortication in Patients With Malignant Pleural Mesothelioma
Health Research Classification System category Cancer
Extra information provided by this PSP
Original uncertainty examples Is there any indication of the efficiency of pleural decortication according to the stage of tumor at the time it is carried out? ~ Further studies are needed to find out whether Pleurectomy  surgery is beneficial or not. ~ I also talked to people who have had operations to scrape the lung lining which has been successful is there any criteria for either of these treatments?
Comparison None identified
Submitted by Patient ~ Bereaved ~ Patient
Outcomes to be measured Survival
PSP information
PSP unique ID 0025
PSP name Mesothelioma
Total number of uncertainties identified by this PSP. 53  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 16 December 2014