Priority 1 from the Mesothelioma PSP

UNCERTAINTY: Does boosting the immune system (using new agents such as PD-1 or PD-L1) improve response and survival rates for mesothelioma patients? (JLA PSP Priority 1)
Overall ranking 1
JLA question ID 0025/1
Explanatory note Not available for this PSP
Evidence Ongoing study - A Randomized Study of Adjuvant WT-1 Analog Peptide Vaccine in Patients With Malignant Pleural Mesothelioma (MPM) After Completion of Combined Modality Therapy.
Health Research Classification System category Cancer
Extra information provided by this PSP
Original uncertainty examples Anti-oxidants/vitamins in large doses have been given to 'long' survivors of meso (in USA).  Why not in UK? (to boost immune system) ~ Can the immune system be stimulated to fight mesothelioma? ~ Again no one seems to be able to tell me if  extra vitamin tablets will help his immune system?   I now have started to to give him BioCare  multivitamins  to help his immune system after a lot of sickness nausea and not wanting to eat. He has lost over two stones. ~ What research is taking place into ways to strengthen the immune system to fight this disease (ie, acupuncture, nutrition, exercise, meditation, positive outlook)?  I have been having weekly acupuncture since diagnosis and scans show tumour is shrinking slightly.  I am doing all of the above to some degree and would like to know which is the most useful. ~ immune system too low to have any treatment
Comparison None identified
Submitted by Bereaved ~ Patient x2 ~ Carer x2
Outcomes to be measured Survival
PSP information
PSP unique ID 0025
PSP name Mesothelioma
Total number of uncertainties identified by this PSP. 53  (To see a full list of all uncertainties identified, please see the detailed spreadsheet held on the JLA website)
Date of priority setting workshop 16 December 2014